Introduction: Sweet syndrome (SS) characterized by papules, plaques or nodules. SS was divided into three subcategories as classical SS, malignancy associated SS, and drug-induced SS.
Case presentation: We present a case of G-CSF-associated Sweet Syndrome (SS) in a 50-year-old man with the diagnosis of extensive stage small cell lung cancer. We started preemptive methylprednisolone with a diagnosis of the sweet syndrome.
Conclusion: SS is the insidious complication of G-CSF . Clinical suspicion is the key to the early diagnosis.