Salma Siddiqui a, Ajai Singh a, Sabir Ali a, Manish Yadav a, Vaishnavi Pandey a, Dilutpal Sharma b
a Department of Orthopaedic Surgery, King George's Medical University, Lucknow, U.P, India
b Department of Biochemistry, King George's Medical University, Lucknow, U.P, India
Doi: 10.1016/j.jons.2019.02.002 - Article's Language: EN
J Oncol Sci 5 (2019) 13-18
The most aggressive and deadliest form of cancer for adolescence and young adults is osteosarcoma.
Current treatment of osteosarcoma mainly consists of chemotherapy along with surgery has dramatically
improved survival rate. However unfortunately, the survival-rate remained unchanged in its metastatic
stages that might be due to chemoresistance against the treatment of osteosarcoma. Till date, in clinical
applications, there is no precise diagnostic/prognostic marker of osteosarcoma. Metallothioneins are
thiol rich intracellular proteins, which binds to several cytotoxic agents. Metallothionein isoforms
participate actively in numerous physiological and patho-physiological processes like proliferation,
apoptosis, angiogenesis, and the heavy metals detoxification. There are many evidences in literature
which are suggestive of participation of these proteins in carcinogenesis and antitumor therapy.
Furthermore, a number of studies also reveal the important role of metallothioneins in tumor cell defense
mechanism against the radiotherapy by preventing apoptosis. Also in osteosarcoma patients in
comparison to healthy controls, the higher level of metallothioneins levels further indicates their significant
role. Moreover higher level of metallothionein-2A in chemotherapy resistance patients with
osteosarcoma further becomes potential supportive evidence. According to the information available in
the literature, one may accomplish that metallothioneins has a role in osteosarcoma progression and
chemoresistance and may become a potential diagnostic marker as well as a reliable therapeutic target.
However, further multicentric studies are needed in support. A better knowledge of the communication
among metallothioneins in osteosarcoma as well as with chemotherapeutic agents is necessity and may
exposed new perspectives in cancer treatment.