Multiple myeloma (MM) is a plasma cell neoplasia and accounts 10% of the hemopoietic malignancies
with mean age of 55 years and 5% of these disorders have extramedullary (EM) disease named as
plasmacytomas (Pm). Pm is a solitary tumor of plasma cells and may be primary as solitary masses
without bone marrow (BM) involvement or may accompany MM 1e4. Upper respiratory tract is most
common site for EM involvement (80e90%). All the body sites including gastrointestinal tract (about
10%), genitourinary tract, reticuloendothelial system, thyroid, lungs, skin, and testicles can also be
involved 4,5. First case with pancreatic Pm has been reported by Hefferman in 1947.6 Here pancreatic Pm
has been reviewed; clinical, diagnostic prognostic and therapeutic approaches have been discussed.