JOURNAL of
ONCOLOGICAL
SCIENCES

ORIGINAL RESEARCH ARTICLE

The factors determining positive detection rate of 68Ga PSMA PET/CT in patients with early biochemical recurrence prostate cancer
Received Date : 10 Jul 2019
Accepted Date : 16 Oct 2019
Available Online : 24 Oct 2019
Doi: 10.1016/j.jons.2019.10.001 - Article's Language: EN
J Oncol Sci 5 (2019) 100-104
This is an open access article under the CC BY-NC-ND license
ABSTRACT
Aim: To examine predictive markers for high detection rates of 68Ga PSMA-PET/CT in biochemical recurrence (BR) prostate cancer (PCa) patients with low PSA levels. Material and Method: This trial was planned as a retrospective single center study. Patients with BR prostat cancer were included. PSA levels of all patients were lower 2 mg/l. Results: Totally thirty-two men patients with BR PCa were included in this study. 18 (56.3%) patients underwent radical prostatectomy and 14 (43.7%) patients curative intense radiotherapy. The number of patients received adjuvant maximal androgen blokage (MAB) treatment was 15 (46.9%). Median PSA levels was calculated 1.03 mg/l 17 (53.1%) of patients had <1 mg/l PSA levels and 7 (21.8%) of patients <0.5 mg/l. The patients number was 16 in unfavorable intermediate risk group (50.0%), 12 (37.5%) in high group and 4 (12.5%) in very high group. The median PSA doubling time was 6.2 months. The number of patients received adjuvant MAB treatment was 15 and in 14 (93.3%) of patients were found positive lesion in 68Ga PSMA-PET/CT. The number of patients with at least one lesion detected on 68Ga PSMAPET/ CT was 19 (59.4%). In univariate analysis to detect the factors affecting 68Ga PSMA-PET/CT positivity, there was only the presence of adjuvant MAB treatment as statistically significant importance (p < 0.001) and in multivariate analysis, the presence of adjuvant MAB treatment was found to be as statistically significant factor in terms of affecting 68Ga PSMA-PET/CT positivity (p ¼ 0.003). The cut-off value was calculated as 1.12 mg/l in patients with no adjuvant MAB treatment (sensitivity 80% and specificity 83.3%). Conclusion: Clinicians may perform 68Ga PSMA PET/CT in low PSA levels to detect lesions in biochemical recurrent prostate cancer patients who had received MAB treatment and in patients with higher PSA levels who had no received MAB treatment.
KAYNAKLAR
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