Immuno-oncology is a very popular field of medical science right now and developments on melanoma therapy have been absolutely marvelous for medical oncologists. Following these recent improvements, I remembered Irvin Yalom's novel “Schopenhauer Cure”. Because the book was narrating a psychotherapist who died from malignant melanoma. I think after all current innovations including BRAF, MEK inhibitors, and check point inhibitors, the novels' ‘end’ would be change. It is really exciting to have scientific developments that may change the end of the story in the book even though it is published less than ten years.