Nasopharyngeal Metastasis from Uterine Leiomyosarcoma
Received Date : 13 Jul 2023
Accepted Date : 15 Dec 2023
Available Online : 28 Dec 2023
Doi: 10.37047/jos.2023-98802 - Article's Language: EN
Journal of Oncological Sciences. 2024;10(1):65-8.
This is an open access article under the CC BY-NC-ND license
Uterine leiomyosarcoma constitutes one of the rare gynecological cancers and contributes to less than 1% of female genital tract cancers. Being one of the rare sites for metastasis development, metastasis of uterine neoplasms in the nasopharyngeal region is extremely rare. A 53-year-old multiparous woman with FIGO Stage Ib uterine leiomyosarcoma presented with nasal congestion 1 year following primary treatment. Paranasal computed tomography revealed a nasopharyngeal mass. The immunohistochemical study demonstrated that tumor cells were stained negative for desmin, h-caldesmon, and estrogen receptor, and were positive for p16 and Ki67. The proliferative index was 50 to 60%, confirming the nasopharyngeal metastasis of uterine leiomyosarcoma. No distant metastasis or local recurrence was evident in her systemic radiological evaluation. The patient received curative radiotherapy after nasopharyngeal mass excision, following which systemic chemotherapy was initiated. After the completion of treatment, the patient was followed for 9 months without recurrence or metastasis. These findings demonstrated that local treatments for metastases will contribute to patient survival.
  1. Abeler VM, Røyne O, Thoresen S, Danielsen HE, Nesland JM, Kristensen GB. Uterine sarcomas in Norway. A histopathological and prognostic survey of a total population from 1970 to 2000 including 419 patients. Histopathology. 2009;54(3):355-364. [Crossref]  [PubMed] 
  2. Skorstad M, Kent A, Lieng M. Uterine leiomyosarcoma-incidence, treatment, and the impact of morcellation. A nationwide cohort study. Acta Obstet Gynecol Scand. 2016;95(9):984-990. [Crossref]  [PubMed] 
  3. Bartosch C, Afonso M, Pires-Luís AS, et al. Distant metastases in uterine leiomyosarcomas: the wide variety of body sites and time intervals to metastatic relapse. Int J Gynecol Pathol. 2017;36(1):31-41. [Crossref]  [PubMed] 
  4. Wroński M, de Palma P, Arbit E. Leiomyosarcoma of the uterus metastatic to brain: a case report and a review of the literature. Gynecol Oncol. 1994;54(2):237-241. [Crossref]  [PubMed] 
  5. Leitao MM, Brennan MF, Hensley M, et al. Surgical resection of pulmonary and extrapulmonary recurrences of uterine leiomyosarcoma. Gynecol Oncol. 2002;87(3):287-294. [Crossref]  [PubMed] 
  6. Pautier P, Genestie C, Rey A, et al. Analysis of clinicopathologic prognostic factors for 157 uterine sarcomas and evaluation of a grading score validated for soft tissue sarcoma. Cancer. 2000;88(6):1425-1431. [Crossref]  [PubMed] 
  7. Brooks SE, Zhan M, Cote T, Baquet CR. Surveillance, epidemiology, and end results analysis of 2677 cases of uterine sarcoma 1989-1999. Gynecol Oncol. 2004;93(1):204-208. [Crossref]  [PubMed] 
  8. Lakhman Y, Veeraraghavan H, Chaim J, et al. Differentiation of uterine leiomyosarcoma from atypical leiomyoma: diagnostic accuracy of qualitative mr imaging features and feasibility of texture analysis. Eur Radiol. 2017;27(7):2903-2915. [Crossref]  [PubMed]  [PMC] 
  9. D'Angelo E, Prat J. Uterine sarcomas: a review. Gynecol Oncol. 2010;116(1):131-139. [Crossref]  [PubMed] 
  10. Seagle BL, Sobecki-Rausch J, Strohl AE, Shilpi A, Grace A, Shahabi S. Prognosis and treatment of uterine leiomyosarcoma: a National Cancer Database study. Gynecol Oncol. 2017;145(1):61-70. [Crossref]  [PubMed] 
  11. Meyer I, Shklar G. Malignant tumors metastatic to mouth and jaws. Oral Surg Oral Med Oral Pathol. 1965;20:350-362. [Crossref]  [PubMed] 
  12. Tohyama T, Sakamoto K, Tamura K, et al. Pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: a case report and literature review. World J Surg Oncol. 2020;18(1):109. [Crossref]  [PubMed]  [PMC] 
  13. Liu YH, Lin BB, Lv SX. Nasopharyngeal metastasis from colorectal cancer: a case report. Ann Palliat Med. 2021;10(4):4911-4816. [Crossref]  [PubMed] 
  14. Liu WW, Guo ZM, Zeng ZY. [Clinicopathological features and prognosis of nasopharyngeal adenocarcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009;44(3):232-236. [PubMed]